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There are several matches for 'transmembrane transcriptional regulator'.
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1271 matches
showing page 1 of 64
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organism
protein
1)
Homo sapiens
SNF8 - Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of
transmembrane
proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in
transcription
regulation
by participating in derepression of
transcription
by RNA polymerase II, possibly via its interaction with [...]
[a.k.a. D6RBI1, NP_009172.2, D6RJ86]
2)
Homo sapiens
MBTPS2 - Membrane-bound
transcription
factor site-2 protease; Involved in
regulated
intramembrane proteolysis (RIP) that is the cleavage of membrane-spanning regulatory proteins by proteases within the plane of the membrane. It cleaves sterol-regulatory element- binding proteins (SREBPs) within the first
transmembrane
segment, thereby releasing the N-terminal segment with a portion of the
transmembrane
segment attached. Mature N-terminal fragments shuttle to the nucleus and activate gene
transcription
. Involved in RIP-mediated
regulation
of bone formation.
[a.k.a. NM_015884, UPI000021249B, AAD08632.1]
3)
Homo sapiens
BMPR1B - Bone morphogenetic protein receptor type-1B; On ligand binding, forms a receptor complex consisting of two type II and two type I
transmembrane
serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD
transcriptional
regulators
. Receptor for BMP7/OP-1 and GDF5. Positively
regulates
chondrocyte differentiation through GDF5 interaction.
[a.k.a. ENST00000512312.5, BMR1B_HUMAN, R-HSA-162582]
4)
Homo sapiens
BMPR1A - Bone morphogenetic protein receptor type-1A; On ligand binding, forms a receptor complex consisting of two type II and two type I
transmembrane
serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD
transcriptional
regulators
. Receptor for BMP2, BMP4, GDF5 and GDF6. Positively
regulates
chondrocyte differentiation through GDF5 interaction. Mediates induction of adipogenesis by GDF6. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
[a.k.a. R-HSA-162582, CD292, ENSP00000492290]
5)
Homo sapiens
GNA12 - Guanine nucleotide-binding protein subunit alpha-12; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various
transmembrane
signaling systems. Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF12/LARG). GNA12-dependent Rho signaling subsequently
regulates
transcription
factor AP-1 (activating protein-1) (By similarity). GNA12-dependent Rho signaling also
regulates
protein phosphatese 2A activation causing dephosphorylation of its target proteins. Promotes tumor cell invasion and metastasis by activating RhoA/ROCK sign [...]
[a.k.a. R-HSA-388396, gep, R-HSA-162582]
6)
Homo sapiens
ACVRL1 - Serine/threonine-protein kinase receptor R3; Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important
regulator
of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I
transmembrane
serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD
transcriptional
regulators
. May bind activin as well.
[a.k.a. ACVRL1-206, 2.7.11.30, KU177888]
7)
Homo sapiens
ACVR2A - Activin receptor type-2A; On ligand binding, forms a receptor complex consisting of two type II and two type I
transmembrane
serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD
transcriptional
regulators
. Receptor for activin A, activin B and inhibin A. Mediates induction of adipogenesis by GDF6 (By similarity).
[a.k.a. CAA44839.1, ENST00000404590, R-HSA-1502540]
8)
Homo sapiens
ACVR1C - Activin receptor type-1C; Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I
transmembrane
serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD
transcriptional
regulators
, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis.
[a.k.a. R-HSA-1502540, R-HSA-162582, NP_001104503.1]
9)
Homo sapiens
AMHR2 - Anti-Muellerian hormone type-2 receptor; On ligand binding, forms a receptor complex consisting of two type II and two type I
transmembrane
serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD
transcriptional
regulators
. Receptor for anti-Muellerian hormone; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
[a.k.a. A0AVE1, XM_011538183, H3BPI9]
10)
Homo sapiens
BMPR2 - Bone morphogenetic protein receptor type-2; On ligand binding, forms a receptor complex consisting of two type II and two type I
transmembrane
serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD
transcriptional
regulators
. Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but enhanced by the presence of type I receptors for BMPs. Mediates induction of adipogenesis by GDF6.
[a.k.a. U25110, BMPR2-203, R-HSA-162582]
11)
Homo sapiens
ACVR1 - Activin receptor type-1; On ligand binding, forms a receptor complex consisting of two type II and two type I
transmembrane
serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD
transcriptional
regulators
. Receptor for activin. May be involved for left-right pattern formation during embryogenesis (By similarity); Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
[a.k.a. XM_011512108.3, NM_001105.4, NM_001105]
12)
Homo sapiens
GNA13 - Guanine nucleotide-binding protein subunit alpha-13; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various
transmembrane
signaling systems. Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF1/p115RhoGEF, ARHGEF11/PDZ-RhoGEF and ARHGEF12/LARG). GNA13-dependent Rho signaling subsequently
regulates
transcription
factor AP-1 (activating protein-1) (By similarity). Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway. Inhibits CDH1-mediated cell adhesion in process independent from Rho a [...]
[a.k.a. L22075, R-HSA-388396, NM_006572]
13)
Homo sapiens
VPS25 - Vacuolar protein-sorting-associated protein 25; Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of
transmembrane
proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in
transcription
regulation
, possibly via its interaction with ELL. The ESCRT-II complex may be involved in f [...]
[a.k.a. DERP9, ESCRT-II complex subunit VPS25, ENSP00000253794]
14)
Homo sapiens
CASK - Peripheral plasma membrane protein CASK; Multidomain scaffolding protein with a role in synaptic
transmembrane
protein anchoring and ion channel trafficking. Contributes to neural development and
regulation
of gene expression via interaction with the
transcription
factor TBR1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1; Belongs to the MAGUK family.
[a.k.a. NP_003679, UPI0000140385, 3MFS]
15)
Homo sapiens
WNT2 - Protein Wnt-2; Ligand for members of the frizzled family of seven
transmembrane
receptors. Functions in the canonical Wnt signaling pathway that results in activation of
transcription
factors of the TCF/LEF family. Functions as upstream
regulator
of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by
regulating
the proliferation of dopaminergic precursors and neurons (By similarity).
[a.k.a. X07876, uc003viz.4, IRP]
16)
Homo sapiens
VSTM2A - V-set and
transmembrane
domain-containing protein 2A; Plays a role in the
regulation
of the early stage of white and brown preadipocyte cell differentiation. Promotes adipogenic commitment of preadipocytes by increasing gene expression of the
transcription
factor PPARG in a BMP4-dependent signaling pathway.
[a.k.a. F8W8J5, MGC33530, NP_001304772]
17)
Mus musculus
Snf8 - Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of
transmembrane
proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in
transcription
regulation
by participating in derepression of
transcription
by RNA polymerase II, possibly via its interaction with [...]
[a.k.a. NP_291046, Snf8-201, ENSMUSG00000006058]
18)
Mus musculus
Mbtps2 - Membrane-bound
transcription
factor site-2 protease; Involved in
regulated
intramembrane proteolysis (RIP) that is the cleavage of membrane-spanning regulatory proteins by proteases within the plane of the membrane. It cleaves sterol-regulatory element- binding proteins (SREBPs) within the first
transmembrane
segment, thereby releasing the N-terminal segment with a portion of the
transmembrane
segment attached. Mature N-terminal fragments shuttle to the nucleus and activate gene
transcription
. Involved in RIP-mediated
regulation
of bone formation; Belongs to the peptidase M50A family.
[a.k.a. Yy2, R-MMU-381119, R-MMU-381033]
19)
Mus musculus
Bmpr1b - Bone morphogenetic protein receptor type-1B; On ligand binding, forms a receptor complex consisting of two type II and two type I
transmembrane
serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD
transcriptional
regulators
. Receptor for BMP7/OP-1. Receptor for GDF5. Positively
regulates
chondrocyte differentiation through GDF5 interaction.
[a.k.a. XM_006500939, UPI000000417C, XP_006501007.1]
20)
Mus musculus
Bmpr1a - Bone morphogenetic protein receptor type-1A; On ligand binding, forms a receptor complex consisting of two type II and two type I
transmembrane
serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD
transcriptional
regulators
. Receptor for BMP2, BMP4, GDF5 and GDF6. Positively
regulates
chondrocyte differentiation through GDF5 interaction. Mediates induction of adipogenesis by GDF6 ; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
[a.k.a. 12166, ENSMUST00000171343, Q53Z43]
1271 matches
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